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lumefantrine will lower the extent or influence of ethinylestradiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.fedratinib will enhance the stage or outcome of ethinylestradiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on. Regulate dose of medication which can be CYP3A4